Ewing Sarcoma The dangerous Cancer: 8 Symptoms to look For

Posted on:
Ewing Sarcoma
On this article you will find

Ewing sarcoma is a rare type of cancer that primarily affects children and young adults.

It is a malignant tumor that typically arises in the bones or soft tissues.

Ewing sarcoma most commonly occurs in the long bones of the body, such as the legs, pelvis, and arms, but it can also develop in other areas such as the chest wall, spine, and skull.


The exact cause of Ewing sarcoma is not yet fully understood.

However, research suggests that it arises from specific changes or mutations in the DNA of cells, leading to uncontrolled cell growth and the formation of tumors.

There are typically specific chromosomal translocations found in Ewing sarcoma, most commonly a fusion between the EWSR1 gene from chromosome 22 and an ETS family transcription factor gene (such as FLI1) from chromosome 11.

This fusion event results in the formation of an abnormal protein that contributes to the development of the cancerous cells.

While the precise triggers for these genetic mutations are unknown, there are some risk factors that may increase the likelihood of developing Ewing sarcoma, including:

  • Age: Ewing sarcoma primarily affects children and young adults, with the highest incidence occurring during the teenage years.
  • Gender: It is slightly more common in males than in females.
  • Genetic predisposition: Some research suggests that certain inherited genetic conditions may increase the risk of developing Ewing sarcoma, although the majority of cases are not associated with a specific genetic syndrome.
  • Exposure to radiation: Previous exposure to high levels of radiation (such as for the treatment of other cancers) may increase the risk of developing Ewing sarcoma.
  • Environmental factors: There is ongoing research investigating potential associations between it and environmental factors, but no clear links have been established so far.


The symptoms of Ewing sarcoma can vary depending on the location and extent of the tumor. Common symptoms include:


The pain experienced with Ewing sarcoma can vary depending on the location of the tumor.

Common areas where it may occur include the long bones of the arms or legs, pelvis, ribs, spine, or skull.

The pain associated can be persistent and worsen over time.

It may initially be mistaken for a sports injury or growing pains, especially in children and adolescents. The pain may be localized to the site of the tumor and can become more intense with movement or at night.

Swelling or lump

Ewing sarcoma can cause swelling or a noticeable lump in the affected area. This can occur around the bone or soft tissues.

A noticeable lump or swelling may be present at the site of the tumor. This can be felt or seen in some cases.

Restricted mobility

In some cases, Ewing sarcoma can cause restricted mobility as the tumor grows and puts pressure on surrounding tissues, joints, or structures.

The restricted movement may result from pain, muscle weakness, or the tumor’s direct interference with the bone or nearby joints.

For example, if the tumor is located near a joint, it may limit the range of motion and cause stiffness or difficulty in moving that joint.

Restricted mobility may develop as the disease progresses or if the tumor grows larger and affects nearby structures.

Bone fractures

Ewing sarcoma typically develops in the long bones of the body, such as the arms, legs, pelvis, or ribs.

It can also occur in the soft tissues surrounding the bone.

As the tumor grows, it weakens the affected bone, making it more susceptible to fractures.

Therefore, if a bone affected by Ewing sarcoma is subjected to stress or trauma, it is more likely to fracture compared to a healthy bone.

Fractures caused by Ewing sarcoma can occur spontaneously, or they may result from minimal trauma or even normal daily activities.

These fractures are often referred to as “pathologic fractures” because they occur due to the weakening and destruction of the bone by the tumor.

Pathologic fractures caused by Ewing sarcoma may be painful and associated with swelling or deformity at the fracture site.


Fatigue, defined as extreme tiredness or lack of energy, can be a common symptom experienced by individuals with cancer, including Ewing sarcoma.

However, it is important to note that fatigue can be caused by various factors, such as cancer treatments, emotional stress, pain, changes in sleep patterns, anemia, and overall impact of the disease on the body.

Weight loss

Weight loss, while not a consistent symptom, may occur in individuals with advanced or metastatic Ewing sarcoma.

Weight loss in cancer is often associated with factors such as decreased appetite, changes in metabolism, and the body’s increased energy needs due to the presence of the disease.


Fever is not a typical symptom of Ewing sarcoma.

However, in some cases, it is possible for fever to occur if the cancer has spread to other parts of the body or if there is an infection or inflammation present as a result of the tumor.

Infection or inflammation related to Ewing sarcoma is rare, but it can lead to fever in some cases.


Anemia, on the other hand, refers to a condition where there is a decrease in the number of red blood cells or a decrease in the amount of hemoglobin in the blood.

Anemia can be caused by various factors such as nutritional deficiencies, chronic illnesses, genetic disorders, or other types of cancers.

However, it’s important to note that it can cause bleeding, and in some cases, it may result in anemia as a secondary symptom.

In instances where Ewing sarcoma involves organs or tissues that produce blood cells (such as bone marrow), it can potentially lead to anemia.


Ewing sarcoma is a rare but aggressive type of bone cancer that primarily affects children and young adults.

It arises from primitive cells in the bone and can spread to other parts of the body.

Symptoms may include pain, swelling, and fractures in the affected area.

Early and accurate diagnosis is crucial for effective treatment.

A combination of imaging techniques, such as X-rays, MRI, and biopsy, are used to diagnose and stage the disease.

Treatment typically involves a multi-modal approach, including chemotherapy, surgery, and radiation therapy.

Prognosis and outcome vary depending on the stage and extent of the disease, as well as individual factors.

While it can be challenging to treat, advancements in medical technology and treatment options have improved survival rates in recent years.

Supportive care, including pain management, physical therapy, and psychosocial support, is essential for patients and their families throughout the treatment journey.

Further research and awareness are needed to better understand the underlying causes, develop more targeted therapies, and improve overall outcomes for affected individuals.

Through ongoing scientific advancements and comprehensive care, it is hoped that progress will be made in the battle against this rare and aggressive form of bone cancer.


What is Ewing sarcoma?

Ewing sarcoma is a rare type of cancer that primarily affects bone or soft tissue in children and young adults.

What are the symptoms of Ewing sarcoma?

Symptoms may include pain, swelling, and tenderness near the affected area, difficulty or pain while moving the affected limb, fatigue, and unexplained weight loss.

What causes Ewing sarcoma?

The exact cause of Ewing sarcoma is unknown, but it is believed to involve genetic mutations in bone cells.

How is Ewing sarcoma diagnosed?

Diagnosis typically involves imaging tests (such as X-rays, MRI, or CT scans), a biopsy to examine tissue samples, and various laboratory tests.

What are the treatment options for Ewing sarcoma?

Treatment may consist of a combination of chemotherapy, surgery to remove the tumor, and radiation therapy. The specific treatment plan depends on the extent and location of the cancer.

What is the prognosis for Ewing sarcoma?

The prognosis varies depending on factors such as the stage of the cancer, the age of the patient, and whether the cancer has spread. Early diagnosis and appropriate treatment can improve the chances of a positive outcome.

Can Ewing sarcoma be prevented?

Unfortunately, there are no known ways to prevent the development of Ewing sarcoma at this time.

What is the long-term outlook for survivors of Ewing sarcoma?

Survivors may require long-term follow-up care to monitor for potential complications or late effects of treatment. Regular check-ups and surveillance are important for ongoing health management.

How useful was this post?

Click on a star to rate it!

Average rating 0 / 5. Vote count: 0

No votes so far! Be the first to rate this post.

As you found this post useful...

Follow us on social media!

We are sorry that this post was not useful for you!

Let us improve this post!

Tell us how we can improve this post?

Follow us on Google News

Related Articles

4 Remedies to prevent Hemorrhoids: Ingredients in Kitchen

4 Home Remedies to prevent Hemorrhoids: Ingredients in Your Kitchen

Hemorrhoids can be uncomfortable and even painful. These swollen veins in the rectum and anus can cause itching, pain, and bleeding. While there are actual effective treatments are available, many …

Read the article icon left
Toothaches in Children: 5 Natural Remedies and What to Avoid

Natural Remedies for Toothaches in Children: What Works and What to Avoid

Toothaches in children can be a stressful experience, both for the child and the parent. The pain can interfere with eating, sleeping, and your child’s overall well-being. While it’s always …

Read the article icon left
Scabies Itch

How to Relieve Scabies Itch with Natural Ingredients

Sarcoptes scabiei, commonly known as scabies, is a parasitic mite that causes intense pruritus (itching), rashes, and lesions. Although infestation is not life threatening, scabies is a nuisance disease that is …

Read the article icon left
icon top